Candida albicans is a fungus that is part of the normal human microbiome. Mucosal membranes such as the mouth, GI tract, and female reproductive tract are common sites for C. albicans colonization. The symptoms of Candidiasis depend on the site of infection. Mucosal infections such as thrush (mouth) and yeast infections (vagina) are generally self-limiting. However under certain circumstances C. albicans can transition from a commensal to a fungal pathogen capable of causing an invasive life-threatening infection. Mortality rates for individuals with invasive candidiasis can range from 30-60%.
Our research focuses characterizing the molecular aspects of how C. albicans interacts with the human host. Specifically, Our laboratory is interested in the transcription factors that regulate C. albicans virulence traits. Students in the laboratory have the opportunity to learn basic microbiology techniques, microscopy, fungal virulence assays, as well as several molecular biology methods. The molecular biology techniques we use in the lab include cloning, restriction digests, PCR, qRT-PCR, gel electrophoresis, DNA/RNA sequencing, and DNA, RNA or protein extractions. Students interested in research opportunities should contact Dr. Glazier via email or through the contact page.